Research

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Baby Brain Recovery Study

Title: Perinatal Stroke: Longitudinal Assessment of Infant Brain Organization and Recovery through Neuroexcitability, Neuroimaging and Motor Development
Dates: September 2021-June 2025
Project #: 7R01HD098202-02
Funding Agency: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development and National Institute of Neurological Disorders and Stroke
Brief Explanation: This study will assess, over the first two years of life, concurrent recovery and development of the infant brain and resultant function after perinatal stroke. 
Eligibility: 0-6 months of age, history of early brain injury, accompanied by a parent/legal guardian.
Please contact our team to help determine eligibility and learn more about the study
Tasks: There are three elements to this study: Imaging, Connectivity, and Movement. Imaging will consist of taking photos of the child’s brain (MRI) while they are naturally sleeping. We test brain connectivity with brief and painless pulses applied from a device that rests gently on your baby’s head (TMS). We assess how your baby is moving and developing by observing your baby’s movement. Check out the Tests and Interventions page on our website to learn more about these methods.  
Time: 8-9 study sessions (3-4 hours each) over 2 years 
Visit time points:  (corrected for prematurity): 0-2, 3-6, 12, 18, and 24 months 
Compensation: $50 at each session, for a total of $450
Planning Your Visit: The visits will take place at the University of WisconsinMadison
Waisman Center, 1500 Highland Avenue.  
Free parking will be provided on the day of your visit
More Information: ClinicalTrials.gov (NCT number): NCT05013736
Current Status: Recruitment for children with early brain injury will be starting soon.
Contact Us: Interested in participating? Questions about the study? Call us at 806-381-2699 or email us at brainrecovery@pediatrics.wisc.edu.

Teleneuromodulation in Children with Cerebral Palsy

Title: Teleneuromodulation in Children with Cerebral Palsy (tDCS)
 Transcranial Direct Current Stim
Dates: May 2021-April 2022
Funding Agency: 2020 American Academy of Cerebral Palsy and Developmental Medicine Research Grant, funded by the NIH
through the National Pediatric Rehabilitation Resource Center
Brief Explanation: Families will work with our team to perform a first-of-its-kind remote, in-home teleneuromodulation study.
Eligibility: 8-17 years old, history of perinatal stroke/brain bleed
Tasks: Virtually meet with the study team to complete each session in the comfort of your own home; set up the headgear; rest during sessions of stimulation (tDCS) through the sponge pads; move small blocks using one hand; complete surveys
Time: 5 consecutive days (about 1 hour per day)
Compensation: $100 gift card
Current Status: Coming Soon
Contact Us: Interested in participating? Questions about the study? Call us at 806-381-2699 or email us at brainrecovery@pediatrics.wisc.edu.

Perinatal Brain Injury: Identifying Cortical Excitability and Circuitry through Multi-Modal Assessment

Title: Perinatal Brain Injury: Identifying Cortical Excitability and Circuitry through Multi-Modal Assessment
Dates: August 2019-July 2021
Project #: NIH 1R21HD097575-01A1
Funding Agency:
National Institutes of Health/NICHD
Brief Explanation: To identify correlations between brain structure, function and computational modeling in children with perinatal stroke.
Current Status: Recruitment Closed, Analysis in Process

Studies During Covid-19 Pandemic

“Disrupted access to therapies and impact on well-being during the COVID-19 pandemic for children with motor impairment and their caregivers” Many children with childhood-onset disabilities affecting physical and cognitive function need early and continuous therapies to address their needs and optimize outcomes. COVID-19 disrupted access to therapy services, with unknown impact on child and caregiver well-being. Caregivers completed an online survey regarding the impact of COVID-19 on access to therapy services and physical/mental health. We found that access to pediatric rehabilitation therapies was disrupted for the majority of families during the first few months of the COVID-19 pandemic, with Telehealth options available to some but not all families. Disrupted access may be related to physical and mental health impacts such as decline in mobility and increased caregiver stress. With the expansion of telehealth, caregiver and child feedback should be incorporated to optimize benefit.

“Assessing the feasibility of at-home neurorehabilitation: Applications for children with cerebral palsy and limited mobility during the COVID-19 Mandate”. The COVID-19 stay at home mandate has changed the landscape of rehabilitation, and will likely require an increased capacity to deliver effective remote rehabilitation. Our lab and others have shown that neuromodulation may be an effective strategy to enhance the effects of standard rehabilitation interventions. This study was an initial step in the assessment of feasibility to perform mock remote neuromodulation (tDCS-transcranial direct current stimulation) in children with cerebral palsy (CP) and has since been published in Brain Stimulation. We found that parent-child teams have the ability to perform the steps required for future remote tDCS. Our next study, now funded by an American Academy of Cerebral Palsy NIH C-PROGRESS grant, will assess the safety, tolerability and feasibility of remotely monitored real tDCS for children with CP.